Thousands of Egyptian anti-government protesters clashed Friday with police in Cairo and other cities, presenting the most serious challenge to President Hosni Mubarak's 30-year rule (Click here to read more on events in Egypt). The demonstrations follow on the heels of similar uprisings in Tunisia and Yemen. In light of these events, what do you think is the most critical issue facing the U.S. in its Middle East policy?

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This is not a scientific poll.