Published April 03, 2012
Women tend to find it harder to quit smoking than men, and a new study suggests why — women's brains respond differently to nicotine, the researchers say.
When a person smokes, the number of nicotine receptors in the brain — which bind to nicotine and reinforce the habit of smoking — are thought to increase in number.
The study found in men, this is true — male smokers had a greater number of nicotine receptors compared to male nonsmokers. But surprisingly, women smokers had about the same number of nicotine receptors as nonsmokers.
"When you look at it by gender, you see this big difference," said study researcher Kelly Cosgrove, an assistant professor of psychiatry at Yale University School of Medicine.
The findings are important because the main treatments for people who want to quit smoking are nicotine-replacement therapies, such as nicotine patches and gums. The study suggests women smokers may benefit more from other types of treatment that don't involve nicotine, including behavioral therapies, such as exercise or relaxation techniques, and non-nicotine containing medications, Cosgrove said.
Elements of smoking not related to nicotine, such as the smell and act of holding a cigarette, may play a greater role in fueling the habit of women smokers, compared with men, Cosgrove said.
Locating nicotine receptors
Cosgrove and colleagues scanned the brains of 52 men and 58 women, about half of whom were smokers. The researchers examined nicotine receptors in the brain by using a radioactive marker that binds specifically to an important group of receptors that are primarily responsible for the body's physical dependence on nicotine, Cosgrove said.
Smokers in the study had abstained from smoking for a week so that their nicotine receptors would be free to bind to the marker used for imaging.
The researchers found that male smokers had about 16 percent more nicotine receptors in an area of their brain known as the striatum, 17 percent more in the cerebellum, and 13 to 17 percent more in the cortical region, or outside layer, of the brain compared with male nonsmokers. Female smokers, on the other hand, had similar numbers of nicotine receptors in these brain regions.
Why are female brains different?
Dr. Len Horovitz, a pulmonary specialist at Lenox Hill Hospital in N.Y., agreed more attention should be paid to non-nicotine related smoking therapies.
"You can replace all the nicotine you want, and people might still want to smoke," Horovitz said. For instance, smoking is a big stress reliever for some people. Even the act of deep breathing is a part of the habit, and breathing exercises may help smokers because they mimic puffing a cigarette, Horovitz said.
The reason for the sex difference seen in the study is not known, but it may have something to do with levels of the hormone progesterone. Levels of this hormone fluctuate in females depending on the stage of the menstrual cycle, and are much higher after ovulation. The study found higher levels of progesterone were associated with a lower number of available nicotine receptors, the researchers said, suggesting progesterone may indirectly block these receptors.
The study is published in the April issue of Archives of General Psychiatry.