Big Ang’s health is at stake.

The “Mob Wives” star, whose real name is Angela Raiola, is once again battling cancer, reports TMZ.

The site adds that Big Ang, 55, went to the doctor last week for a normal checkup when she learned her cancer had returned and is appearing in other areas of her body.

In April, Big Ang had a tumor the size of a lemon removed from her throat and doctors also removed her left lymph nodes during an eight-hour procedure. Months later, she underwent a second surgery on the right side of her throat.

“Things happen for a reason,” she told People in September. “I’d smoked for 40 years. No one could tell me what to do.” She added that she quit smoking the day she initially found out about her cancer.

“It’s hard to just put down the cigarette and never look back,” she continued. “I enjoy smoking. I miss it so much. But it’s over. Now I do the e-cigarette. It helps me, just to hold it in my hand.”

A request for comment from her rep was not immediately returned.

This article originally appeared in the New York Post's Page Six.