Jennifer Aniston and Owen Wilson reunite for the first time since "Marley & Me" for the slapstick rom-com "She's Funny That Way."

In this hilarious behind-the-scenes look of a Broadway production, Wilson plays Arnold, a stage director who begins a relationship with an escort and aspiring actress Isabella (Imogen Poots), despite being married to the star of his show, Delta (Kathryn Hahn).

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Due to a twist of comedic fate, Isabella gets a casting call for Arnold's play, without his knowledge. When she shows up, playwright Joshua (Will Forte) falls head over heels for her, even though he's dating therapist Jane Claremont (Aniston).

As it so happens, Isabella is also one of Jane's patients, and has no idea about her relationship with Joshua.

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Written and directed by Peter Bogdanovich, this is the filmmaker's first directorial effort since the 2007 documentary "Tom Petty and the Heartbreakers: Runnin' Down a Dream."

"She's Funny That Way" hits theaters May 1.