She’s earned a notorious reputation for being one of Hollywood’s most difficult actresses to work with – and now Katherine Heigl won’t play nice with Duane Reade either.

The gorgeous, but grumpy, “Grey’s Anatomy” star slapped the pharmacy giant with a $6 million-plus lawsuit Wednesday alleging she was photographed without consent by paparazzi outside one of its Manhattan stores — and that Duane Reade then brazenly misused the image for its own advertising.

The 35-year-old Heigl – who’s repeatedly been ripped by industry sources for routinely inflating production costs by complaining about scripts, her wardrobe and other on-set issues — filed the suit in Manhattan federal court alleging the photo was taken “without consent.”

She says that Duane Reade then wrongfully tried to profit off it by distributing the snapshot with the chain’s promotional slogans on its official Facebook and Twitter accounts without her “knowledge or approval.”

The image first popped up March 18 on a Tweet on Duane Reade’s official page, saying “Love a quick #DuaneReade run? Even @KatieHeigl can’t resist shopping at #NYC’s favorite drugstore.”

Click here for more on the lawsuit from the New York Post.