"The Rosie Show" debuts at 7 p.m. ET on the Oprah Winfrey Network (OWN). And while O'Donnell had a hit in the late '90s with "The Rosie O'Donnell Show," this time, things are a bit more complicated.
"It's been tough for OWN," Brad Adgate, senior vice president of research at New York's Horizon Media company, told USA Today. "I don't think anyone affiliated with Discovery (which shut down its Discovery Health channel to launch OWN with Winfrey) has been happy with the ratings."
Secondly, O'Donnell has become increasingly controversial since her first talk show went off the air, most famously when she publicly battled with Trump during her short time as moderator on "The View." But this time around -- with British comedian Russell Brand as her first guest -- O'Donnell thinks can charm people all over again.
"I think when people see me back in their living rooms every night, they're going to remember and say, 'Oh, I liked her.' And I think any kind of preconception or media-conjured negativity is not going to be a part of it," she told USA Today.
We'll see about that ... in the meantime, from O'Donnell to Jerry Springer to Dr. Phil, let us know: Who's the worst talk show host of all time?