Charlie Sheen won't be going back to work any time soon.
The decision was based on the "totality of Charlie Sheen's statements, conduct and condition," the companies said in a joint statement Thursday.
The show's future was not addressed.
Production had already been suspended in January to allow Sheen to seek rehabilitation after he was admitted tot he hospital after an alleged 36-hour cocaine and booze bender.
Earlier Thursday, Warner and Sheen's publicist, Stan Rosenfield, said the series would resume taping next week. That was before the 45-year-old actor's rambling, often vitriolic radio interview with host Alex Jones in which Sheen blasted "Two and a Half Men" executive producer Chuck Lorre.
In his interview with Jones, Sheen, apparently calling from the Bahamas and in the company of two women, repeatedly evoked violent images and ideas. He also derided Lorre in an attack that reeked of anti-Semitism.
"There's something this side of deplorable that a certain Chaim Levine -- yeah, that's Chuck's real name -- mistook this rock star for his own selfish exit strategy, bro. Check it, Alex: I embarrassed him in front of his children and the world by healing at a pace that his unevolved mind cannot process," Sheen said.
"Last I checked, Chaim, I spent close to the last decade effortlessly and magically converting your tin cans into pure gold. And the gratitude I get is this charlatan chose not to do his job, which is to write," he said.
Lorre, who was born Charles Levine, is a veteran producer whose hits include "The Big Bang Theory," "Dharma & Greg" and "Cybill."
Sheen also made fun of Alcoholics Anonymous. He referred to it as a "bootleg cult" with a 5 percent success rate, compared to his own "100 percent" success rate.
One of the group's mottos, he said, is, "'Don't be special. Be one of us.' News flash: I am special and I will never be one of you."
When Jones told Sheen he sounded like Thomas Jefferson, Sheen dismissed the founding father, calling Jefferson a "p***y."
Sheen referred to himself as a new sheriff in town who has an "army of assassins."
"If you love with violence and you hate with violence, there's nothing that can be questioned," said Sheen.
Sheen also mentioned that his ex-wife Brooke Mueller had been with him in the Bahamas, but was no longer. He wished her luck in her travels, before saying cryptically, "You'll need it,"
He also said he was 100 percent drug free, repeating an assertion he had made to RadarOnline.com shortly before news of his show's suspension broke.
"These a**holes claim they know this, and we are going to prove them wrong," Sheen told the website, referring to producer's fears he had fallen off the wagon. Sheen to take a drug test on Monday at his Mulholland Estate mansion.
"Blood, urine, whatever, we're testing it," he said. "I'm so confident where I am at and that these faceless names can't touch me. I know that I will pass the test and prove my detractors wrong. If they do discover my blood to be tiger blood, I hope that nobody will be shocked."
Lorre had no comment on Sheen's remarks or the production shut down, a show rep said Thursday. A call made after business hours Thursday to the publicist for Sheen's co-star, Jon Cryer, was not returned.
Sheen, however, did not go silent after the CBS and Warner announcement.
In what TMZ dubbed an "open letter" from Sheen that the website posted Thursday, the actor called Lorre a "contaminated little maggot" and wished the producer "nothing but pain."
Sheen, improbably, also called on his fans to start a protest movement for him.
"I urge all my beautiful and loyal fans who embraced this show for almost a decade to walk with me side-by-side as we march up the steps of justice to right this unconscionable wrong," he wrote.
Sheen, whose film credits include "Platoon," "Wall Street" and "Major League," signed a new two-year contract at the end of last season that reportedly pays him about $1.8 million per episode.
Warner had already planned to cut this season's 24 planned episodes to 20 because of the hiatus. Now, CBS is left with a total of 16 episodes of its cornerstone Monday comedy, all of which have aired.
But Sheen's behavior may cost him more that his "Two and a Half Men" paycheck. The actor is slated to star in "Major League 3," but the film's producer said he'll get someone else if Sheen doesn't clean up his act.
"Obviously with 'Major League 3' there's a huge part written for Charlie's character ... but after dealing with Lindsay Lohan on 'Georgia Rule,' I can speak for someone who has experienced the difficulties of working with an actor dealing with addiction," producer James G. Robinson, the CEO of Morgan Creek Productions, told TMZ. "I won't go through that again. If Charlie doesn't straighten up, I unfortunately can't put him in the movie."
"When Lindsay was doing 'Georgia Rule,' she would miss full days of work," Robinson said. "When an actor doesn't show up for work, you can lose half-a-million dollars a day paying the 250 other people there for the shoot and the costs for the set."
- The Associated Press contributed to this report.